Dr. Anthony Fauci, former director of the National Institute of Allergy and Infectious Diseases, invoked his Fifth Amendment right against self-incrimination 111 times during a congressional hearing concerning COVID-19. This action has drawn significant criticism from readers of the New York Post.

Several readers expressed that Fauci's repeated use of the Fifth Amendment was "reprehensible but predictable," suggesting his silence lent credence to the tactics employed during the pandemic. Concerns were raised about perceived harms inflicted upon Americans, including educational disruptions for children due to mask mandates and job losses stemming from vaccine requirements. One reader described Fauci's legacy as that of a "vile mad scientist" consumed by self-adulation and profit at the expense of millions.

Critics also pointed to what they perceived as arrogance and a lack of accountability. One letter stated that Fauci's demeanor during the hearing was "smug," while another described his "blank, dead eyes" and "zombie-like demeanor," suggesting he acted as if the over a million COVID-19 deaths in the U.S. were merely data points.

Comparisons were drawn to former President Donald Trump's invocation of the Fifth Amendment over 440 times during a 2022 investigation into his business practices, with some readers questioning the selective outrage. They noted that Republicans and right-wing media outlets, which widely denounced Fauci's actions, had been largely silent regarding Trump's similar use of the Fifth Amendment.

Another point of contention for readers was Fauci's continued receipt of a federal pension and research funds, which they felt was incongruous with his actions and contrasted with the consequences faced by other public servants for less severe indiscretions. The possibility of contempt charges was also mentioned by some.

Some letters defended Fauci to a degree, asserting that he should not be blamed for the national and international effects of COVID-19, as the virus was not created or first discovered in the United States. However, the dominant sentiment among the published letters focused on the perceived betrayal of public trust and Fauci's handling of the pandemic.