Christina Applegate is reportedly experiencing a significant health crisis, with friends noting her condition has worsened and she is now "almost unable to move." The situation comes after the actress was misdiagnosed with multiple sclerosis (MS), a condition she publicly revealed she had in 2021.

Applegate, 54, had become a prominent advocate for MS awareness after her diagnosis. However, recent reports suggest a new, "horrific" health challenge has emerged, causing concern among her close circle.

Despite battling debilitating symptoms for over five years, Applegate recently revealed that her doctor informed her she does not have multiple sclerosis. This revelation adds a layer of complexity to her ongoing health struggles.

Christina Applegate has revealed her doctor told her she does not have multiple sclerosis (MS) – despite battling debilitating symptoms for more than five years. Pictured in 2023

The actress, known for her roles in "Married with Children," "Friends," and "Anchorman," has been candid about the challenges posed by her diagnosed condition, including difficulties with mobility. In 2022, she attended the Hollywood Walk of Fame ceremony with her husband Martyn LeNoble and daughter Sadie Grace LeNoble, leaning on a cane.

Applegate, joined by daughter Sadie Grace LeNoble, husband Martyn LeNoble, and Nancy Priddy, poses with Applegate's Hollywood Walk of Fame star in 2022

Her public disclosure of the MS diagnosis in 2021 marked a significant moment, as she detailed the physical toll the disease had taken. The news of her current health crisis has drawn concern from fans and colleagues alike.