Baltimore Ravens quarterback Lamar Jackson sustained a right thumb injury on his first offensive snap in Sunday's game against the Buffalo Bills, forcing him out of the game. The injury occurred as Jackson's thumb hit the shoulder and arm of Bills defensive end Greg Rousseau while throwing the football.

Jackson immediately showed signs of pain and was taken to the Ravens' medical tent before being escorted to the locker room with a towel wrapped around his hand. Initially deemed questionable to return, the team later announced Jackson was done for the game.

Tyler Huntley replaced Jackson at quarterback for the Ravens. This marks another setback for Jackson, who had been sidelined for the previous three games with a high-ankle sprain suffered in an Oct. 4 victory over the Tennessee Titans. Before Sunday's injury, Jackson had a productive season, completing 68 of 96 passes for 967 yards, six touchdowns, and one interception, while also contributing 144 rushing yards and a touchdown. The Ravens had a 3-1 record in his starts this season prior to the Bills game.