College football's opening weekend is set to feature several high-profile matchups, with a notable emphasis on potential upsets. Three favored teams—Auburn, UNLV, and Clemson—are highlighted as being particularly vulnerable in their Week 1 contests.

Auburn Tigers vs. Baylor Bears

The Auburn Tigers, facing the Baylor Bears in a neutral-site game in Atlanta, are considered to be at risk of an upset. Auburn is introducing a new coaching staff led by head coach Alex Golesh and a significant number of new players. This transition period, combined with the neutral venue, creates a scenario ripe for unexpected results. While Auburn defeated Baylor convincingly last season, that outcome involved a different coaching regime and roster, rendering it largely irrelevant for this matchup. The betting line favors Auburn by 7.5 points, but the possibility of Baylor covering or winning outright is considered.

UNLV Rebels vs. Hawaii Rainbow Warriors

The UNLV Rebels, who were favored by three points against the Hawaii Rainbow Warriors, are now facing increased upset potential after observing Week Zero performances. UNLV struggled defensively against Memphis in their season opener, a performance that could indicate lingering issues for their game in Honolulu. Conversely, Hawaii showed resilience in their Week Zero loss to Stanford, leading midway through the fourth quarter as underdogs. The challenge of trans-Pacific travel for UNLV, coupled with the sting of an opening loss, could spell trouble. A potential 0-2 start for UNLV could lead to scrutiny of head coach Dan Mullen's tenure.

Matt Byrnes runs into Keyvone Lee

Clemson Tigers vs. LSU Tigers

A significant Week 1 matchup features the Clemson Tigers against the LSU Tigers, with LSU favored by 10 points. This game carries added intrigue as both teams have undergone coaching changes and faced off in a highly anticipated contest last season. LSU, now led by Lane Kiffin, has also been involved in recent controversies regarding players returning to college football. These off-field distractions could impact their focus. Despite the betting spread, the talent disparity between the teams is not perceived as vast, with Clemson possessing strong receiving talent and a capable front seven. The performance of Clemson's starting quarterback, Christopher Vizzina, in his second career start at Death Valley will be a key factor. Analysts suggest that Clemson has the potential to challenge LSU, and an upset is not out of the question.

LSU Tigers CB Mansoor Delane celebrates a defensive stop against the Clemson Tigers at Memorial Stadium in South Carolina.