A reported confrontation between Prime Minister Sir Keir Starmer and his chief of staff, Morgan McSweeney, over the appointment of Lord Peter Mandelson as Britain's ambassador to the United States has become the focal point of a widening political crisis, The Mail on Sunday reported.

The newspaper quoted a "highly placed source" saying Starmer returned to 10 Downing Street after a Commons session dominated by questions about Mandelson's links to the late Jeffrey Epstein and erupted: "You are supposed to be protecting me from things like this!" The Mail on Sunday said McSweeney replied: "That's exactly what I was trying to do!" No 10 has denied the encounter occurred as described and initially said Mr McSweeney was not in the country before conceding he had been in Downing Street earlier that day.

The episode comes as questions about the process that led to Lord Mandelson's appointment have intensified. According to multiple Whitehall and security sources cited by the Mail, the Foreign Office was largely excluded from the recruitment and vetting process after Mr McSweeney pushed for Mandelson, a former European commissioner and Labour minister, to be posted to Washington following the election of Donald Trump in the United States.

Security officials told the newspaper they produced a single report that flagged a number of concerns, including Lord Mandelson's past contacts with Epstein and business links with Russia and China. The Mail quoted a senior government official as saying the initial document contained stronger warnings but was "rewritten" before it reached the prime minister; No 10 denied the advice was "sexed down." The Foreign Office and security services have not publicly confirmed the detailed contents of the report cited in the press.

The emergence of material linking Lord Mandelson with Epstein intensified scrutiny. US congressional panels released portions of a so-called "birthday book" compiled by Ghislaine Maxwell that included a brief note attributed to Mandelson. The Mail reported that US officials had urged No 10 to keep the incumbent ambassador, Karen Pierce, in post or to consider other candidates such as MI6 chief Sir Richard Moore, who, a source said, "could actually be trusted with sensitive material." The incoming US administration, the newspaper said, preferred continuity in Washington while the diplomatic posting was resolved.

Inside Whitehall, the Mail and sources it quoted described a widening role for Lord Mandelson inside No 10 after his appointment was announced, with McSweeney increasingly relying on his advice on both foreign and domestic matters. One official, cited by the paper, said the relationship prompted colleagues to nickname Mr McSweeney "the Real Foreign Secretary." The same accounts link Mandelson to decisions in an autumn reshuffle, and to the redeployment of figures such as Business Secretary Jonathan Reynolds to chief whip and the appointment of Peter Kyle as business secretary.

The Labour frontbench has also been unsettled by the fallout. The Mail reported that despairing Labour MPs are looking to Manchester Mayor Andy Burnham as a potential rallying point, with Lucy Powell said to be running as his "proxy" in a deputy leadership contest that could pave a route back to the Commons and, potentially, a leadership bid. The Guardian, in a column cited by the Mail, said there were "below-the-radar operations to oust the Prime Minister," and that doubts about Starmer's political judgment were spreading among MPs. Labour figures contacted by other outlets have been circumspect about predictions of imminent leadership moves.

Foreign Office officials described an internal effort to draw up questions for Lord Mandelson about his contact with Epstein and other matters after the congressional disclosures. Sir Olly Robbins, the department's most senior civil servant, was reported to have convened an ad hoc group of ethics experts to seek answers that, according to sources cited by the Mail, went unanswered for a time. The newspaper said it was at that point Mr McSweeney accepted Lord Mandelson's position had become untenable and informed the prime minister — a sequence that it said precipitated the reported shouting match.

No 10 told the Mail that the account of a heated row was "fabricated" and that the prime minister and his chief of staff did not speak to each other in the manner described. The Downing Street source also said Mr McSweeney had been in No 10 earlier in the day before leaving for Brussels on the 5pm Eurostar.

The Mandelson affair has already had immediate operational consequences inside government. It coincided with the resignation of Deputy Prime Minister Angela Rayner over an unrelated tax issue and with a hastily announced reshuffle. Ministers cited in the Mail suggested Lord Mandelson had been involved in advising on the personnel changes inside No 10.

The dispute has added to broader questions about the role of unelected advisers inside Downing Street and the handling of diplomatic appointments. Officials and former diplomats told the Mail that non-career appointments typically entail more extensive scrutiny and periodic vetting; the reported treatment of Lord Mandelson's security clearance has renewed debate about how such checks are applied to political appointees.

Labour spokespeople and Downing Street declined to expand on the internal discussions cited in press reports, reiterating No 10 denials of the specific encounter described by The Mail on Sunday. The party and government maintain that processes are under review and have said publicly that they will co-operate with any official inquiries into the appointment and vetting procedures.

The Mail on Sunday is the principal source for the detailed description of the exchange and the internal Whitehall accounts cited here. Other outlets have reported separately on the Mandelson disclosures and ensuing questions in Parliament about what information No 10 and security agencies held before the ambassador's appointment was announced. As the political fallout continues, MPs and senior officials said decision-makers in Westminster would be watching whether the episode leads to wider moves inside the Labour parliamentary party or formal investigations into appointment procedures.