The White House has issued a critical statement regarding Rosie O'Donnell's recent week as guest host on "Jimmy Kimmel Live," labeling her "a nasty woman and a total slob whose brain has been completely destroyed by Trump Derangement Syndrome."

The statement, attributed to White House spokesperson Davis Ingle and reported by Entertainment Weekly, addressed O'Donnell's continued public commentary on former President Donald Trump during her hosting stint. O'Donnell, who recently returned to the United States to perform a one-woman show and fill in for Kimmel, has a long-standing public feud with Trump.

During her final night hosting on Thursday, O'Donnell made several remarks directed at Trump, including a song parody. She thanked Kimmel for "reminding everyone that we have the right to free speech in this country, whether Orange Voldemort likes it or not." The parody, set to the tune of "Danny Boy," included lyrics such as "But there’s a way to end this drama. It’s time to use that stable-genius brain. Since we all know you’ll never be Obama, why not resign, and make this country great again?"

White House staffers' response echoed language previously used by Trump himself, who has referred to O'Donnell's criticisms as indicative of "Trump Derangement Syndrome." O'Donnell, who moved to Ireland after Trump's reelection, has spoken about her renewed public profile due to their ongoing conflict, referring to him as "Mango Mussolini."

"If he knew how much he was helping my career and my life, he would shut up about me because, you know, he’s a horrible creature," O'Donnell was quoted as saying regarding Trump's continued engagement with their feud.