An 11-year-old boy from Tucson, Arizona, has been diagnosed with idiopathic multicentric Castleman disease, an extremely rare disorder that affects the immune system and causes lymph nodes to enlarge. Giovanni Cruz was hospitalized in June after suddenly experiencing severe chest and back pains.
His mother, Patricia Cruz, recounted that Giovanni had been active, playing baseball, when he began complaining of pain and sweating profusely. His condition worsened rapidly, prompting an immediate trip to Tucson Medical Center and later transfer to Banner Diamond Children’s Medical Center.
Idiopathic multicentric Castleman disease affects approximately three Americans per million, according to the provided notes. The illness triggers an overactive immune response, leading to widespread inflammation that can impact vital organs.
Giovanni's case is multicentric, meaning the disease affects lymph nodes throughout his body. Unlike some forms of Castleman disease where a single affected lymph node can be surgically removed, his condition requires a different treatment approach. He has undergone numerous medical procedures, including multiple biopsies, MRIs, CT scans, echocardiograms, ultrasounds, X-rays, and blood tests.
Doctors noted fluid buildup around his abdomen, lungs, and heart, which caused breathing difficulties and necessitated supplemental oxygen. Giovanni has also experienced kidney complications and persistent fevers. He is currently receiving treatment that includes IL-6-directed therapy, high-dose IV steroids, and dialysis. His treatment and monitoring are expected to continue for six to eight weeks, with chemotherapy potentially being considered if he does not respond adequately to his current regimen.
The cause of idiopathic multicentric Castleman disease remains unknown. The disease can affect organs such as the liver, kidneys, and bone marrow. It is unclear how long Giovanni will remain hospitalized or how he will respond to the ongoing treatment.
Patricia Cruz has been by her son's side throughout his hospitalization, missing over a month of work. Before falling ill, Giovanni was preparing to start sixth grade and was an active baseball player.
