Alexander Zverev holds a significant advantage entering his quarterfinal match against Botic van de Zandschulp at the 2026 U.S. Open, according to betting odds and match analysis. Zverev is a considerable favorite at -910 to win the match and is listed at +110 to win the tournament, a path that has opened up with early exits from other top contenders.

Zverev's path to the quarterfinals has been a mixed one. He faced lengthy five-set battles in his first two matches against Lorenzo Sonego and Quentin Halys, accumulating over nine hours on court. However, he has since found his form, defeating Alejandro Tabilo and Luciano Darderi in more decisive fashion.

In contrast, Van de Zandschulp had a smoother early run, progressing through his initial matches efficiently. His recent rounds, however, have also involved five-set marathons, including victories over Zizou Bergs and Arthur Gea. While both players have spent a comparable amount of time on court, Zverev is expected to be the fresher of the two due to his more dominant performances in the third and fourth rounds.

The betting analysis suggests that Van de Zandschulp will face pressure to establish an early lead, as he may not have the stamina for a late comeback against the world's third-ranked player. The prediction favors Zverev to control the match and secure a relatively comfortable victory. One specific betting recommendation is Zverev to win by at least 7.5 games at +110 odds.