The San Francisco 49ers are experiencing a concerning surge in injuries less than two weeks into training camp, with close to 20 players sidelined from their 90-man roster as of Wednesday's practice.
Notable absences include Nick Bosa and Dre Greenlaw, both experiencing soreness, as well as Kyle Juszcyk with a finger issue, Mike Evans with a quad injury, De’Zhaun Stribling and Malik Mustapha with hamstring problems, and Christian Kirk with a calf injury. Defensive lineman Sam Okuayinonu also left practice on Wednesday with an apparent ankle issue.
The team's wide receiver corps has been particularly hard hit, with Ricky Pearsall now facing season-ending surgery. The sheer volume of sidelined players could potentially lead the 49ers to cancel their joint practice with the Tennessee Titans on August 11 if they do not have sufficient healthy personnel.
This situation mirrors the injury-plagued 2025 season for the 49ers, which saw key players like Bosa, Fred Warner, and George Kittle sustain season-ending injuries. Quarterback Brock Purdy also dealt with toe issues that impacted his performance. The team ultimately fell short in the NFC Divisional Round.
The team also recently navigated an incident where head coach Kyle Shanahan was involved in a car accident shortly before training camp began. The current rash of injuries adds to the team's challenges as they prepare for the upcoming NFL season, raising concerns about their potential for a deep playoff run in 2026.