The popular weight loss medication Mounjaro, known chemically as tirzepatide, is increasingly being associated with an unexpected side effect: a significant reduction in alcohol cravings and consumption. This observation aligns with emerging research into GLP-1 agonists, the class of drugs to which Mounjaro belongs, suggesting a broader impact on impulsive behaviors beyond appetite suppression.
Grace Parkin, a 34-year-old manager from Sheffield, recounted how her consumption of alcohol changed dramatically after starting Mounjaro in May 2024. Previously, she would consume multiple pints of lager during social outings or up to 10 vodka, lime and lemonades on a Saturday night. However, she found that a pint of beer began to taste unpleasant and made her feel bloated, leading her to drink alcohol only about once a month. She also noted a decreased interest in wine and her usual spirit and mixer.
Parkin, who has struggled with her weight since her teenage years and previously underwent a gastric balloon procedure with limited success, lost six stone in 18 months on Mounjaro. She described the drug as having an almost immediate effect on her appetite, but also on other impulsive behaviors. Before Mounjaro, she would spend disposable income on non-essential items like clothing and holidays, often driven by a desire for an adrenaline rush. Since starting the medication, she reports only buying what she needs.
Research indicates that GLP-1 agonists may influence the brain's reward system, which is implicated in addictive behaviors. Studies have suggested that these medications can reduce the risk of developing alcoholism by 18% and cocaine addiction by 20%. US trials have also indicated a reduction in alcohol cravings among moderate drinkers using GLP-1s.
Parkin temporarily stopped Mounjaro in February in preparation for a cosmetic procedure but has since restarted the medication. She aims to maintain her current weight of 11 stone 10 pounds and credits the drug with providing a "lack of food noise" and overall control, stating she does not plan to stop taking it.