The United Kingdom has approved the first oral GLP-1 weight-loss pill, marking a significant shift in the accessibility of these medications. This development is expected to increase the prevalence of GLP-1 drugs, which have already profoundly impacted the medical field.
Dr. Clair Grainger, an online doctor at Superdrug, addressed common queries regarding the new pill, clarifying its potential effects and usage.
Hair Loss and Weight Loss
Concerns about hair loss are frequently raised with weight-loss medications. Dr. Grainger explains that increased shedding is more likely associated with the weight loss itself, rather than the medication. Significant weight loss in a short period can cause hair follicles to enter a temporary resting phase, leading to shedding. This type of hair loss is typically temporary, with hair growth often returning to normal as the body adjusts. Currently, there is no evidence to suggest that the oral pill carries a higher risk of hair loss compared to injectable GLP-1 medications; the underlying cause remains the rapid change in body weight.
Impact on Sex Drive and Fertility
While changes in libido are not considered a direct side effect, some patients report alterations. Common side effects like nausea or fatigue may temporarily reduce interest in sex. Conversely, weight loss can improve energy levels and confidence, potentially boosting libido. For those considering fertility treatments, Dr. Grainger advises that weight loss may be recommended by some specialists to improve conception chances. However, women actively trying to conceive should not use weight-loss medication. Due to semaglutide's prolonged presence in the body, treatment should be stopped at least two months before attempting to become pregnant. Consultation with a GP or fertility specialist is recommended before altering medication regimens for fertility purposes.
Medication Management and Side Effects
If vomiting occurs shortly after taking the pill, Dr. Grainger advises against taking another dose the same day. Doing so could increase the risk of side effects. Patients should follow the instructions in their patient leaflet and resume their normal dosing schedule the following day, seeking medical advice for severe symptoms.
Oral weight-loss drugs generally do not interfere with oral contraceptives. However, vomiting or diarrhea, potential side effects of GLP-1 drugs, can affect the absorption of other medications. Patients are advised to follow guidance for their contraceptive medication and consult a professional if concerned, as additional protection might be recommended.
Oral Wegovy should be taken at least 30 minutes before any other oral medication.
Alcohol Consumption and Missed Doses
Alcohol does not appear to stop the medication from working, but it can exacerbate common side effects such as nausea, vomiting, and fatigue. Alcohol can also increase appetite, complicate healthy food choices, and in some individuals, contribute to low blood sugar, potentially leading to dizziness or weakness when combined with the medication.
If a dose is missed, patients should not take a double dose the next day or take the forgotten dose later. Instead, the next scheduled dose should be taken as normal. Attempting to compensate for a missed dose can increase the risk of side effects without providing additional benefit.
Interactions with Other Medications
Before starting treatment, it is crucial for patients to have a thorough discussion with their healthcare provider about all medications they are taking, including prescriptions, over-the-counter drugs, and supplements. Some medications may require monitoring, dose adjustments, or specific timing when taken with weight-loss treatments. Particular attention is needed for diabetes medications, blood thinners like warfarin, levothyroxine, other GLP-1 medications, and drugs requiring close monitoring such as lithium, digoxin, and ciclosporin. Patients are urged to inform their prescriber of all substances they are consuming to ensure safe treatment.