John Driskell Hopkins, a founding member of the Zac Brown Band, is actively pursuing his music career while managing his amyotrophic lateral sclerosis (ALS) diagnosis, which he received in 2021. Hopkins described his current approach to life as "chasing the clock," a sentiment driven by a desire to accomplish as much as possible despite the progression of the disease.

In an interview, Hopkins shared that he has become even busier since his diagnosis, prioritizing family vacations and studio time. He continues to tour with the Zac Brown Band, noting that his physical capabilities, particularly his fingers, still allow him to play instruments. While his voice has been affected, he believes most audiences would not notice a significant difference during performances. He is also experimenting with playing different instruments on stage.

Hopkins acknowledged the potential stress his busy schedule might be causing, creating a "catch-22" situation, but remains committed to living fully. He expressed hope that his ALS progression remains slow, allowing him to continue singing for an extended period, though he recognizes the uncertainty of the future.

Reflecting on the 2014 Ice Bucket Challenge, in which he and the band participated before his diagnosis, Hopkins recalled a lack of understanding about the disease's impact. He has since founded the nonprofit organization Hop On A Cure with his wife, Jennifer, to advance research toward preventing, reversing, and curing ALS, while also raising awareness and supporting affected families. The organization has participated in the resurging Ice Bucket Challenge this summer.

Despite his condition, Hopkins stated he does not feel strong, describing his outward appearance of strength as an act stemming from his theater background. He feels fortunate to still be able to plan for the future, looking ahead to performing at the 30a Songwriters Festival in 2027. He emphasized that getting up and continuing his activities each day is his measure of strength, particularly as he is in a unique position compared to the majority of ALS patients who cannot plan as far ahead.