The luteal phase of the menstrual cycle, which begins after ovulation and precedes menstruation, is marked by significant hormonal fluctuations, particularly a substantial drop in estrogen. This phase is also known colloquially as the period of 'luteal uglies,' referencing the range of symptoms some women experience during this time.

The primary hormonal changes during the luteal phase involve the corpus luteum, a temporary endocrine structure, producing progesterone and estrogen. After ovulation, if fertilization does not occur, the corpus luteum degenerates, leading to a sharp decline in both hormones. This hormonal shift can trigger various physical and emotional responses. While the exact mechanisms are still being studied, these changes are thought to influence mood, energy levels, and other bodily functions. The term 'luteal uglies' broadly encompasses a spectrum of premenstrual symptoms, which can vary significantly from one individual to another.