Major U.S. stock indexes fell Wednesday as oil prices surged above $100 a barrel for the first time since July, intensifying concerns about inflation and the potential for the Federal Reserve to raise interest rates.

The Dow Jones Industrial Average dropped approximately 367 points, or 0.7%, by mid-morning ET, while the S&P 500 and Nasdaq experienced similar declines of 0.3% each.

Brent crude futures climbed 2.9% to $100.77 a barrel, and West Texas Intermediate rose 2.9% to $95.73. This jump has reignited fears of prolonged elevated energy prices and higher inflation, potentially leading the Federal Reserve to implement another interest rate hike.

The yield on the U.S. 10-year Treasury briefly touched 4.806%, surpassing the closely watched 4.8% mark, and the 2-year Treasury yield increased to 4.415%. According to Lawrence Gillum, chief fixed income strategist for LPL Financial, this rapid bond sell-off suggests traders are anticipating a rate increase at the Federal Reserve's September meeting.

"A gap of roughly 60 to 85 basis points between the federal funds target range and the 2-year Treasury yield is the market telling you it expects the next move to be a hike, not a cut," Gillum noted in a research report. He added that while the firm believes the threshold for a hike is higher than for holding rates steady, the market's nearly 50% probability of a hike means the risk of market pressure influencing Fed action cannot be dismissed.

Concerns over energy supply disruptions have intensified due to renewed hostilities in the Middle East, specifically related to the Strait of Hormuz, a critical chokepoint for approximately 20% of the world's oil. U.S. Central Command reported late Tuesday that American forces had destroyed five Iranian oil tankers near Kharg Island, a significant energy hub for Iran, in a move seen as an escalation aimed at impacting Iran's economy.

National average gasoline prices have remained high, reaching $4.22 a gallon as of Wednesday, according to AAA. Investors and economists are now awaiting key inflation data, including the Producer Price Index on Thursday and the Consumer Price Index on Friday. This economic data will be the last released before the Federal Reserve's upcoming interest rate decision, a decision that could influence the midterm elections as consumers grapple with rising costs.

The conflict between Iran and the United States has reached the six-month mark, with tensions escalating. Energy Secretary Chris Wright has expressed skepticism about the possibility of reaching a nuclear agreement with Tehran. However, former Trump administration officials have asserted that oil and gasoline prices would decrease rapidly once overseas hostilities cease. Treasury Secretary Scott Bessent suggested oil could fall to $40-$50 a barrel if the Strait of Hormuz were fully reopened, while former President Trump predicted gas prices would drop to $3 and eventually $2 a gallon after the conflict's conclusion.