Rosie O'Donnell has detailed her experience with the weight-loss drug Mounjaro, stating she has experienced no side effects.
On a recent episode of the podcast “Bleep! With Ana Navarro,” O'Donnell, 64, explained that she has been progressing with the medication at a deliberately slow pace. She began with the lowest dose, 2.5 milligrams, for a full year. Subsequently, she spent another year on 5 milligrams. Currently, she is nearing the end of a year on 7.5 milligrams.
O'Donnell indicated that she plans to increase her dosage only one more time before maintaining her current level. She attributed her cautious approach to past experiences with rapid weight loss, which she said could be overwhelming. Her preference for a gradual pace stems from her desire to avoid feeling unwell.
When asked by podcast host Ana Navarro if she had experienced any gastrointestinal issues often associated with GLP-1 medications, O'Donnell responded unequivocally, "Never." She reiterated her adherence to a slow dosage increase, explaining that she initially resisted her doctor's suggestions to go up in dose because she felt comfortable with her existing regimen.
O'Donnell first publicly discussed her use of Mounjaro in January 2023, noting at the time that she had been prescribed the drug, along with Rapatha, two months prior. She described the medication's effect as altering her thought process, significantly reducing her appetite and leading her to forgo cravings for foods like sugary sodas. She reported a substantial decrease in her intake of sugary drinks and processed sugars, opting for water instead.
At that time, she had lost approximately 10 pounds. Over the subsequent years, she has continued to share updates on her weight loss, reportedly shedding around 60 pounds in three years. O'Donnell has referred to Mounjaro as life-saving, expressing a wish for the drug's price to be lowered so that more individuals struggling with obesity could access it. She shared in a July interview that she feels healthier and more empowered in her current physical state, aiming to combat the shame and humiliation often associated with being overweight.