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The Express Gazette
Tuesday, October 13, 2026

Restless Legs Syndrome Drug Linked to Compulsive Behaviors, Lawsuits Allege

Patients report uncontrollable urges for shopping, gambling, eating, and sex while taking pramipexole, leading to legal action.

US Politics • 2 hours ago
Restless Legs Syndrome Drug Linked to Compulsive Behaviors, Lawsuits Allege

A drug widely prescribed for Restless Legs Syndrome (RLS) is facing scrutiny over allegations that it can trigger severe compulsive behaviors, including uncontrollable shopping, gambling, eating, and sexual urges. Patients and their families are filing lawsuits, claiming that manufacturers failed to adequately warn them about these potentially devastating side effects.

Dorothy Moate, a patient who was prescribed pramipexole for her RLS, described experiencing insatiable compulsions, such as shopping online at all hours and baking cakes in the middle of the night. Her home is reportedly filled with unneeded clothing and shoes, a consequence of her compulsive behavior. Moate stated that her doctor made no mention of potential side effects when prescribing the medication.

Similar accounts have emerged from other individuals who have taken pramipexole. These reports detail experiences ranging from excessive gambling and overeating to hypersexuality, with patients often expressing a lack of control over their actions. The emergence of these compulsive behaviors has led to significant personal and financial distress for many.

Pramipexole, sold under brand names like Mirapex, is a dopamine agonist primarily used to treat RLS and Parkinson's disease. Dopamine plays a crucial role in the brain's reward and motivation pathways, and alterations in its signaling are believed to be linked to addictive and compulsive behaviors.

Dorothy was prescribed pramipexole for her restless legs syndrome (RLS). ‘The (doctor) made no mention of any potential side-effects,’ she says, 'so I was happy to take it'

The lawsuits contend that pharmaceutical companies were aware of or should have been aware of the potential for pramipexole to cause these serious behavioral changes. Plaintiffs argue that insufficient warnings on product labeling and in communications with healthcare providers allowed the drug to be prescribed without adequate consideration of the risks.

Dorothy with her overflowing wardrobe – a result of her compulsive behavior. She's also got more than 50 pairs of shoes. ‘I can’t stop myself from going online to buy clothes and shoes, and then more clothes and shoes,' she says

These legal actions seek to hold the manufacturers accountable for the harm caused to patients and their families, demanding compensation for damages related to addiction, financial ruin, and other consequences stemming from the alleged undisclosed side effects of pramipexole.


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