Pamela Anderson revealed that treating her hepatitis C diagnosis in the 1990s consumed her savings, describing the experience as a "death sentence" before effective and accessible treatments were widely available. She was told by doctors that she likely had only a decade to live.

"I was lucky," Anderson stated at a recent fundraiser for AIDS research. "I was offered it in its early stages, and it took everything I had in my bank to pay for it. It wasn’t covered by insurance yet, and I felt tremendous guilt that others weren’t granted the same access."

Anderson was diagnosed with hepatitis C in the late 1990s, a time when the virus was largely incurable. While early medications had less than a 10% success rate in clearing the disease, by 2011, effectiveness had risen to 50-75%. The actress announced she was free of the virus in 2015, by which time new antiviral pills introduced in 2014 could cure over 95% of cases within eight to 12 weeks.

She attributed her contraction of the virus to sharing a tattoo needle with her ex-husband, Tommy Lee. Hepatitis C is transmitted through infected blood, often via shared injection devices, razors, or improperly cleaned sharp objects. According to the CDC, as many as 43% of hepatitis C cases are associated with injection drug use. The virus can also be transmitted from mother to child and, less commonly, through sexual contact.

Hepatitis, a general term for liver inflammation, has five viral types: A, B, C, D, and E. Hepatitis C is a common liver infection in the United States, affecting an estimated 2.4 to 4 million Americans between 2017 and 2020. However, a significant number of individuals with the disease remain unaware of their condition, as symptoms can take decades to manifest. This often leads to delayed diagnosis and treatment, potentially causing lasting liver damage.

Symptoms of hepatitis C typically appear only after the virus has significantly damaged the liver. These can include fatigue, easy bruising or bleeding, loss of appetite, dark urine, and fluid buildup in the abdomen or swelling in the legs. In severe cases, liver failure can occur, leading to liver cancer and death. Chronic hepatitis C is identified as the leading cause of liver cancer and liver transplants in the US.

Anderson has spoken about experiencing lasting "shame and guilt" related to her illness, which she has worked to overcome. She now identifies as a "victor" rather than a "victim."

Screening for hepatitis C is recommended for all adults, as early detection and treatment significantly improve outcomes. Unlike hepatitis A and B, there is currently no vaccine available for hepatitis C.