Despite a significant Week 1 victory over the Dallas Cowboys, the New York Giants have opened as 7.5-point underdogs for their Week 2 road game against the Los Angeles Rams on "Monday Night Football." The betting line has since shifted slightly, with the Rams now favored by 7 points at DraftKings Sportsbook, though over 70 percent of spread bets have landed on the Giants.

The Giants secured a strong start to their season on Sunday, September 13, 2026, with a win at MetLife Stadium. Quarterback Jaxson Dart celebrated the team's performance after coming off the field. The team also demonstrated an ability to control the line of scrimmage and possession in Week 1, rushing for 165 yards and holding the ball for over 36 minutes, marks that would have been among their best from the previous season.

In contrast, the Rams are looking to rebound after a disappointing loss to the San Francisco 49ers in Australia. Adding to their challenges, the Rams' offseason acquisition, Myles Garrett, will undergo knee surgery on Monday and is expected to miss at least the next four games. Garrett had already been limited in training camp due to knee swelling and did not record a tackle in the Week 1 loss. Rams head coach Sean McVay acknowledged that the team initially believed Garrett could play through the injury but decided to change course after game-day realities.

The potential absence of both Garrett and Aaron Donald, whose availability for the game is uncertain, could leave the Rams' defensive front significantly depleted. The Giants, meanwhile, aim to build on their Week 1 success and prove they can compete with top NFL teams, potentially attracting more public support as the Week 2 matchup approaches.