Colts Favored to Extend Titans' Losing Streak
Indianapolis aims to capitalize on Tennessee's struggles in Week 6 matchup.
The Indianapolis Colts, holding a 2-3 record, are favored to win against the Tennessee Titans in their Week 6 NFL matchup. Despite a middling season record, the Colts have shown offensive potential, scoring at least 22 points in four of their five games. Their recent performances include an overtime loss to the undefeated Chiefs and a 30-13 victory over the Texans, along with a 30-13 win against the Commanders in London.
Indianapolis's offense demonstrated its ability to move the ball against Pittsburgh's defense in their last game, though they settled for field goals instead of touchdowns. Quarterback Daniel Jones was seen throwing against the Steelers on October 11, 2026.
The Titans, meanwhile, are struggling significantly, currently holding an 0-5 record and averaging a league-low 11.6 points per game. Their offensive output has faltered, failing to reach double digits in two of their last three games. In their most recent outing, Tennessee managed only three points against a previously winless Houston Texans team, averaging a mere 3.2 yards per play in a 26-3 defeat. Second-year quarterback Cam Ward has struggled to show progress, with the offense scoring 10 or fewer points in three of their five contests. Tennessee Titans’ Cam Ward was seen jogging off the field during a game against the Houston Texans on Sunday, October 11, 2026.
Despite defensive weaknesses, the Colts are expected to have sufficient offensive power to overcome the Titans. Indianapolis has also had recent success against Tennessee, winning the last six meetings between the two AFC South rivals. The Colts are giving seven points, a spread that oddsmakers believe they can cover at home against what appears to be the NFL's least effective offense.