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The Express Gazette
Tuesday, October 27, 2026

Christina Applegate Reveals Ongoing Mobility Issues Post-MS Misdiagnosis

The actress shared on her podcast that she experiences severe difficulty moving and now uses a walker, despite no longer being diagnosed with multiple sclerosis.

US Politics • 2 hours ago
Christina Applegate Reveals Ongoing Mobility Issues Post-MS Misdiagnosis

Christina Applegate is continuing to experience debilitating mobility challenges, sharing new details about her health struggles on a recent episode of her podcast, "MeSsy." Applegate, who was previously diagnosed with multiple sclerosis (MS), revealed that doctors have since informed her she does not have the disease. However, she emphasized that her physical difficulties persist.

"I actually timed it today. It took me ten minutes to be able to move off my pillow and get out of the bed and stand up," Applegate, 54, explained on the podcast she co-hosts with Jamie-Lynn Sigler, who has MS. "I almost couldn’t walk to the bathroom, and now a walker is sitting next to my bed because of what’s going on."

Applegate stated that she has "never" experienced mobility issues this severe before and that she was always able to sit up on her own. She described the current situation as either things getting worse or new symptoms emerging. "It took 10 minutes just to sit my head up, just to move without excruciating pain and weakness," she said.

Last week, Applegate disclosed the news of her misdiagnosis, which came after she had spent five years discussing her perceived battle with MS. "[My doctor] came into my room and said, ‘Congratulations, you don’t have MS,’" she recalled. "I was, like, not happy at all. Everybody else was so happy."

The actress referred to the misdiagnosis as a "mindf—k" and reiterated that her symptoms have not improved. "I haven’t gotten better, Jamie! If anything, I’ve gotten worse," she told Sigler. "So I’m back at square one where I don’t know what’s going on with me."

Applegate's next step is to consult a rheumatologist, a specialist in diseases affecting joints, muscles, and bones. "And you know, we’ll go from there," she said. "If that doesn’t come with any kind of results, then we’re going to go to a different specialist and then a different specialist."

She admitted that doctor's visits can be overwhelming due to the physical effort required. "I think I just have to go, all right, one step at a time. And hoping there are answers out there."

Despite no longer being diagnosed with MS, Applegate vowed to remain an advocate for the MS community. "Even though I don’t have this disease, I’m still your warrior," she stated. "I’m still going to speak out on your behalf forever and ever. I still feel like part of this community and no matter what, I love you."


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