Chrissy Metz revealed in an interview that she is taking a GLP-1 medication to aid in her weight loss journey, having lost approximately 100 pounds over the past year. The 45-year-old actress, known for her role in "This Is Us," stated that her decision came after years of dieting efforts that proved ineffective.

"I'm not getting any younger," Metz told People. "I'm in perimenopause, and there were obesity issues within my family and with my father, and I felt like I've tried so many modalities, whether it was diets or therapy, and none of it really worked for me."

Metz, who has partnered with the digital health company Ro, did not specify which GLP-1 medication she is using or when she began taking it. However, she described her experience with the medication as "great" thus far, despite initial skepticism. She noted a significant benefit in no longer obsessing about food constantly, stating, "It's so nice not to be obsessing about what I'm going to have every minute, even as I'm still consuming the meal."

The actress acknowledged that her decision might attract criticism, but she remains unconcerned about public opinion. "It doesn't matter, because like I always say, they're not in my life," she explained. "They're not in my doctor's notes. They're not in the hereditary issues my family has."

Metz stated she continues to work on building muscle with a trainer and has not set a specific weight loss goal. "I'm just a regular old girl who is trying her best," she asserted.

In April 2025, Metz had previously mentioned to the Daily Mail that she had lost 100 pounds through strength training. At that time, she responded diplomatically when asked about potentially trying Ozempic, a GLP-1 medication. She emphasized the personal nature of such decisions, saying, "It's something I feel like, it is so personal and sure, I think it's important to like destigmatize anything. But I also think it's people's personal decision to decide what it is that they want to do for their body."

Metz also shared her aversion to more invasive medical interventions, noting her hesitancy even with over-the-counter medications. "I don't even take Tylenol, like, I really am such a weirdo that way. I'm like, 'Yeah, no.'"