The San Francisco 49ers are set to face the Seattle Seahawks on Sunday, October 11, 2026, at 4:25 p.m. ET from Lumen Field in Seattle. The 49ers enter the Week 5 contest with a perfect 4-0 record, while the Seahawks stand at 3-1.
San Francisco's defense has been strong, allowing an average of 16.0 points per game through their first four contests. Offensively, the team ranks sixth in the NFL in rushing with 137.3 yards per game and eighth in passing with 251.8 yards per game. Quarterback Brock Purdy has thrown at least two touchdown passes in every game this season, accumulating 1,007 yards and 11 touchdowns with one interception. Running back Christian McCaffrey leads the team with 218 rushing yards and four touchdowns on 50 carries, having scored in each of the last three games. The 49ers' offense converts 57.5 percent of its third downs, the highest rate in the league.
Seattle's defense has allowed an average of 18.25 points per game. The Seahawks are plus-3 in turnover margin, tied for fourth in the league. Their passing game ranks 14th in the NFL at 237.0 yards per game, with Jaxon Smith-Njigba as a primary target, leading the team with 481 receiving yards and six touchdowns on 32 catches. The Seahawks' ground game ranks 13th in the NFL, averaging 110.3 yards per game, led by Emanuel Wilson, who has 190 yards on 53 carries. Wilson ran for 81 yards and a touchdown on 21 carries against the Chargers on October 4.
The Seahawks are 3-point favorites over the 49ers according to DraftKings, with the over/under set at 46.5 points. The moneyline favors Seattle at -161, with San Francisco at +135.
This game can be watched on FOX and streamed via FOX One, which offers a three-day free trial. The broadcast is scheduled to begin at 4:25 p.m. ET.