49ers Injury Report: Key Players Questionable Ahead of Seahawks Clash

The San Francisco 49ers are facing a mixed bag of injury updates for several prominent players as they gear up for their upcoming Sunday game against the Seattle Seahawks. Despite currently leading the NFC West, the team is looking to bounce back after a significant loss to Seattle in the NFC Divisional Round last season. Both teams have seen changes since their last encounter, but the rivalry continues to be intense.

Mike Evans, who played through a broken rib injury in the 49ers' Week 4 victory over the Denver Broncos, is showing encouraging signs. He recorded 76 receiving yards on five receptions in that game. On Thursday, Evans was observed running on a side field in uniform, indicating he was active though not participating in full team practice. His availability for Sunday's game against Seattle remains uncertain, but his experience would be a valuable asset against a strong Seahawks defense.

Defensive lineman Mykel Williams appears poised to make his season debut against Seattle. Williams has been recovering from a torn ACL and lateral meniscus in his right knee, an injury sustained in November 2025. His participation in Thursday's practice suggests he is ready to play in Week 5.

Nick Bosa continues to be hampered by a calf injury and is expected to miss his third consecutive game. He was seen working separately from the team during Thursday's practice.

Christian McCaffrey and Trent Williams, both key offensive players, practiced fully on Thursday after taking a rest day on Wednesday. They are expected to be available for the Week 5 matchup.