The Toronto Blue Jays will face the San Francisco Giants on Wednesday afternoon in a highly anticipated pitching matchup featuring two of the league's notable arms. The game is expected to be a low-scoring affair, with a run total set at seven.

The Blue Jays will start Dylan Cease, who has posted a 2.79 earned run average over 16 starts this season and is considered a Cy Young Award contender. The Giants will counter with Logan Webb, who has a 3.66 ERA and 78 strikeouts in just over 93 innings pitched.

The Giants' home ballpark is known for being pitcher-friendly, ranking sixth in fewest total runs allowed and second in fewest home runs allowed in 2026, according to Statcast. This, combined with the offensive struggles of both teams, suggests that runs will be scarce.

Toronto's offense is averaging 3.92 runs per game, the second-lowest in the league, while San Francisco is averaging 4.16 runs per game, the eighth-lowest. The under on the total run count is 20-18-3 in home games for the Giants, which is the third-best mark in MLB.

Despite the matchup being considered close to a coin flip, the Blue Jays are slightly favored at -105. Cease's strong performance and potential regression for Webb, based on peripheral statistics like average exit velocity, contribute to this outlook. Predictions favor the Blue Jays on the moneyline and the under seven total runs.