Longevity researchers are increasingly turning to fisetin, a naturally occurring plant polyphenol, for its potential to combat aging by targeting senescent cells, often referred to as 'zombie cells.' This compound, available in capsule form, is being incorporated into the regimens of those exploring advanced anti-aging strategies.
Fisetin is classified as a senolytic, meaning it has the ability to selectively eliminate senescent cells. These cells accumulate over time and can release inflammatory molecules that damage surrounding tissues, potentially prompting nearby cells to also become senescent. While human studies on fisetin are still limited, preliminary research, including studies on mice, has shown promising results.
In animal studies, chronic fisetin supplementation has been linked to improvements in healthspan, the period of life spent in good health, and has also extended both median and maximum lifespan in mice. These findings have encouraged some researchers to experiment with the compound. For instance, Harvard researcher David Sinclair reportedly takes approximately 500 mg of fisetin daily.
Supplements containing fisetin are available from various brands, with some formulations offering enhanced absorption. Reviewers have reported noticing improvements in mental clarity and energy levels, with some experiencing better sleep and increased resilience to stress with consistent use. As with any supplement, it is advisable to consult a physician before beginning use.
Fisetin is part of a broader trend in the wellness industry focusing on longevity, which includes popular trends like NAD+ supplements and comprehensive anti-aging protocols.