Druski, making his hosting debut on "Saturday Night Live," delivered a memorable performance that included a sketch spoofing convicted fraudster Elizabeth Holmes. The comedian transformed himself into the Theranos founder for a parody segment titled "You Can See Everything."

Adding to the night's notable moments, newly elected Texas lawmaker James Talarico made a surprise appearance during the show's cold open. Talarico, who recently secured a victory in Texas, turning the state blue for the first time since 1988, was humorously introduced as "Senator Talafreako" by Druski. Talarico's cameo came just days after his electoral success.

The episode also featured a cameo from actress Emma Stone. Other highlights and lowlights from the broadcast were later compiled and shared.